Comparison of Natural Honey and Metformin on Pancreatic Histopathology in STZ- Induced Diabetic Rats

Authors

  • Khaneshi, Fereshte Department Of Biology, Faculty of science, Urmia University, Urmia, Iran
  • Nasrolahi, Ozra Department Of Biology, Faculty of science, Urmia University, Urmia, Iran
  • Rahmani, Fatemeh Department Of Biology, Faculty of science, Urmia University, Urmia, Iran
Abstract:

 Background& Objective: The use of natural antioxidants is a new approach in controlling diabetes. In this study, the effect of natural honey (a powerful antioxidant) was compared with metformin (a prevalent drug used for diabetes) on histological changes of pancreas in diabetic rats.Materials& Methods: 30 male rats, weighting 180-220 gram were randomly divided into six groups including C: non ­diabetic rats receiving distilled water (0.5 ml), CH: non diabetic rats receiving honey (1g/kg b.w), CD: diabetic rats administered with distilled water (0.5 ml), D.H: honey treated diabetic rats (1g/kg b.w), DM: Metformin administrated-diabetic rats (100 mg/kg), and DMH: Metformin + honey-co-treated diabetic animals.Diabetes was induced by a single dose of Streptozotcin (65 mg/kg i.p). The animals were treated by oral gavage daily for a month. After treatment, the pancreatic tissues of the animals were excised, prepared, and stained with H & E method.Results: The results showed that the diameter and the number of islands of the pancreas in diabetic control rats have more significant decrease (p<0.001) than non-diabetic control rats. Diameter of the islands in DMH group had significant increase compared with DH and DM groups (p<0.05). Moreover, atrophy and destruction of the islet cells and the nucleus were observed in DC group. We faced improvement of these complications in treatment groups.Conclusion: Natural honey can have healing effect on the pancreas tissue of diabetic rats. Due to the antioxidant properties of honey, combination of honey and metformin can have restorative effect on pancreatic tissue repair in diabetic rats.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effect of natural honey from Ilam and metformin for improving glycemic control in streptozotocin-induced diabetic rats

Objective(s): Diabetes mellitus is a public health problem and one of the five leading causes of death globally. In the present study, the effect of Metformin with natural honey was investigated on glycemia in the Streptozotocin-induced diabetic rats. Materials and Methods: Thirty Wistar male rats were randomly divided into six groups including C: non ‌diabetic rats received distilled water, C...

full text

Comparative Effects of Metformin and Glibenclamide on Aortic Reactivity to Vasodilator and Vasoconstrictor Agents in STZ-Induced Diabetic Rats

Background: Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main reason cause of disability and death in diabetic patients and death. The present study investigates the effects of metformin and glibenclamide on vasoconstrictive and vasodilative responses in the diabetic rat aorta. Methods: Rats were divided into four experimental groups (con...

full text

Silymarin: a novel natural agent to restore defective pancreatic beta cells in Streptozotocin (STZ)-induced diabetic rats

This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic  cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Silymarin: a novel natural agent to restore defective pancreatic beta cells in Streptozotocin (STZ)-induced diabetic rats

This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic  cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...

full text

The effect of date aqua extract and melatonin on diabetic neuropathy in STZ-induced diabetic rats

Introduction: Diabetes mellitus is often associated with chronic neuropathy, a condition which is due to the disturbance in the function of peripheral nervous system. Studying the effects of antioxidants in relieving neuropathy is of a great clinical importance. The aim of this study was to compare the effect of aqua extract of date and Melatonin in preventing neuropathic hyperalgesia in Strept...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 4  issue 3

pages  335- 343

publication date 2014-11

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023